- Title
- Zinc, zinc transporters and Type 2 Diabetes
- Creator
- Myers, Stephen; Nield, Alex
- Date
- 2014
- Type
- Text; Book chapter
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/100647
- Identifier
- vital:10578
- Identifier
- ISBN:9781922227300 (ISBN); 9781922227782 (ISBN)
- Abstract
- Insulin resistance is an important characteristic of Type 2 Diabetes (T2D) and is commonly associated with obesity, hypertension and cardiovascular disease (Carsten, 2000; Hulver and Lynis, 2004). Insulin resistance reduces insulin-stimulated glucose disposal due to multiple post-recepter intracellular defects in insulin signaling with subsequent reductions in glucose transport, glucose oxidation and incorporation of glucose into glycogen (Abdul-Ghani and DeFronzo, 2010; Peppa et al., 2010). The intracellular post-receptor regulatory effects of insulin include the regulation of the cellular glucose transport system, adaptive changes in gene expression and subsequent biosynthesis and action of the enzymes involved in the preservation of metabolism, and the modulation of genes that contribute to increased pro-mitotic, proliferative and anti-apoptotic activity of cells (Taton et al., 2010). Accordingly, the reduced activity of insulin action in any, or all of these post-receptor regulatory actions is insulin resistance. Given that insulin resistance usually precedes the development of T2D and is a major component of the progressive nature of this disease (Pagel-Langenickel et al., 2010), understanding the pathophysiology of insulin resistance will enable the development of therapeutic strategies to prevent or manage disease progression. Although many theories have been forthcoming, the primary mechanism of insulin resistance remains largely elusive.
- Publisher
- iConcept Press
- Relation
- Endocrine diseases Chapter 2 p.
- Rights
- Copyright © iConcept Press 2014
- Rights
- This metadata is freely available under a CCO license
- Subject
- Zinc; Zinc transporters; Type 2 diabetes; Ionic zinc
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