- Title
- The adsorption and release characteristics of CPFX in porous starch produced through different drying methods
- Creator
- Gao, Fei; Li, Dong; Bi, Chonghao; Mao, Zhihuai; Adhikari, Benu
- Date
- 2013
- Type
- Text; Journal article
- Identifier
- http://researchonline.federation.edu.au/vital/access/HandleResolver/1959.17/37481
- Identifier
- vital:5249
- Identifier
-
https://doi.org/10.1080/07373937.2013.815627
- Identifier
- ISSN:0737-3937
- Abstract
- The drug adsorption and release characteristics of porous starches produced through hot air drying, spray drying, and vacuum freeze drying were investigated using ciprofloxacin as model drug. A UV/visible spectrophotometer, Fourier-transform infrared spectrometer, differential scanning calorimeter, and X-ray diffractometer were used to determine the drug adsorption/release, drug/starch interaction, glass transition, and crystallinity of porous starch samples. The amount of ciprofloxacin adsorbed in three different porous starches was 5.58%, 8.91%, and 11.43%, respectively. The ciprofloxacin-loaded porous starches had glass-transition-related endothermic peaks between 55°C and 65°C and melting-related endothermic peaks between 120°C and 150°C. Up to 75% of the loaded ciprofloxacin was released from the freeze-dried sample within 30 hrs. The freeze-dried porous starch also showed higher ciprofloxacin loading rate, higher glass transition temperature, and higher ciprofloxacin release rate. A two-phase dynamic drug release model was found to satisfactorily fit the release kinetics of ciprofloxacin (R2 > 0.995). © 2013 Copyright Taylor and Francis Group, LLC.; C1
- Relation
- Drying Technology Vol. 31, no. 13-14 (2013), p. 1592-1599
- Rights
- © 2013 Copyright Taylor and Francis Group, LLC.
- Rights
- This metadata is freely available under a CCO license
- Subject
- 0904 Chemical Engineering; Adsorption; Ciprofloxacin; Drying; Porous starch; Release kinetics
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